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- Title
Computational methods for identification of functional residues in protein structures.
- Authors
Xin, Fuxiao; Radivojac, Predrag
- Abstract
The recent accumulation of experimentally determined protein 3D structures combined with our ability to computationally model structure from amino acid sequence has resulted in an increased importance of structure-based methods for protein function prediction. Two types of methods for function prediction have been proposed: those that can accurately predict overall biochemical or biological roles of a protein and those that predict its functional residues. Here, we review approaches used for the computational identification of functional residues in protein structures and summarize their applications to a wide variety of problems in functional proteomics, such as the prediction of catalytic residues, post-translational modifications, or nucleic acid-binding sites. We examine four different problems in order to perform a comparison between several recently proposed methods and, finally, conclude by identifying limitations and future challenges in this field.
- Publication
Current protein & peptide science, 2011, Vol 12, Issue 6, p456
- ISSN
1875-5550
- Publication type
Journal Article
- DOI
10.2174/138920311796957685