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- Title
Advanced mass spectrometry-based methods for the analysis of conformational integrity of biopharmaceutical products.
- Authors
Bobst, Cedric E; Kaltashov, Igor A
- Abstract
Mass spectrometry has already become an indispensable tool in the analytical armamentarium of the biopharmaceutical industry, although its current uses are limited to characterization of covalent structure of recombinant protein drugs. However, the scope of applications of mass spectrometry-based methods is beginning to expand to include characterization of the higher order structure and dynamics of biopharmaceutical products, a development which is catalyzed by the recent progress in mass spectrometry-based methods to study higher order protein structure. The two particularly promising methods that are likely to have the most significant and lasting impact in many areas of biopharmaceutical analysis, direct ESI MS and hydrogen/deuterium exchange, are focus of this article.
- Publication
Current pharmaceutical biotechnology, 2011, Vol 12, Issue 10, p1517
- ISSN
1873-4316
- Publication type
Journal Article
- DOI
10.2174/138920111798357311