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- Title
Lenalidomide for treatment of myelodysplastic syndromes.
- Authors
Komrokji, Rami S; List, Alan F
- Abstract
Lenalidomide is a second generation immunomodulatory agent (IMiD), which currently represents the standard of care for treatment of transfusion dependent lower risk myelodysplastic syndrome (MDS) patients with deletion (5q). Lenalidomide has unique activity with a high transfusion independence rate observed in this subset of patients. In this article we summarize the clinical experience using lenalidomide for treatment of del (5q) MDS. We highlight the mechanism of action and the recent advances in understanding the biology of del (5q) MDS. We also explore its potential use and the efforts to further improve its activity in non-del (5q) MDS.
- Publication
Current pharmaceutical design, 2012, Vol 18, Issue 22, p3198
- ISSN
1873-4286
- Publication type
Journal Article
- DOI
10.2174/1381612811209023198