We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Kinase inhibitor conjugates.
- Authors
Harmsen, Stefan; Kok, Robbert Jan
- Abstract
In the last decade kinase inhibitors have emerged as a new class of very potent and relatively safe anticancer drugs. However, despite their success, off-target toxicities and induction of rapid resistance are major drawbacks that highly compromise successful longterm administration. In the current review, we provide an overview of the approaches that have been undertaken to overcome these issues by conjugation of these agents to carriers that enable their cellular and/or intracellular targeted delivery. Eventually, targeting kinase inhibitors will provide powerful treatment options not only for cancer, but also for other less-life threatening diseases that involve deregulated kinase signaling pathways.
- Publication
Current pharmaceutical design, 2012, Vol 18, Issue 20, p2891
- ISSN
1873-4286
- Publication type
Journal Article
- DOI
10.2174/138161212800672778