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- Title
Safety and efficacy of baclofen in the treatment of alcohol-dependent patients.
- Authors
Addolorato, Giovanni; Leggio, Lorenzo
- Abstract
Preclinical studies show that antagonism of the GABA(B) receptor may represent an effective neuropharmacological approach to treat alcohol dependence. Consistent with preclinical evidence, the majority of the human studies have demonstrated that the prototype GABA(B) receptor antagonist baclofen may represent an effective mediation to treat alcohol-dependent individuals. Specifically, baclofen has shown to reduce alcohol withdrawal symptoms, as well as to reduce alcohol craving and intake, and to promote alcohol abstinence. Notably, baclofen has shown a safe profile when administered to alcoholics, including those with liver cirrhosis. In summary, baclofen represents a safe and effective medication to treat alcohol dependence, thus holding promise as a new pharmacotherapy. However, large studies are needed to confirm the present findings.
- Publication
Current pharmaceutical design, 2010, Vol 16, Issue 19, p2113
- ISSN
1873-4286
- Publication type
Journal Article
- DOI
10.2174/138161210791516440