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- Title
Folate and homocysteine metabolism: therapeutic targets in cardiovascular and neurodegenerative disorders.
- Authors
Mattson, Mark P; Haberman, Frank
- Abstract
Individuals with elevated homocysteine levels are at increased risk for cardiovascular disease and stroke, and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases Homocysteine is a modified form of the amino acid methionine that is tightly regulated by enzymes requiring folate. By impairing DNA repair mechanisms and inducing oxidative stress, homocysteine can cause the dysfunction or death of cells in the cardiovascular and nervous systems. Dietary folate stimulates homocysteine removal and may thereby protect cells against disease processes. The enzymes involved in homocysteine and folate metabolism provide novel targets for drug discovery.
- Publication
Current medicinal chemistry, 2003, Vol 10, Issue 19, p1923
- ISSN
0929-8673
- Publication type
Journal Article
- DOI
10.2174/0929867033456864