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- Title
Sequence recognition of DNA by lexitropsins.
- Authors
Goodsell, D S
- Abstract
Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits--pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.
- Publication
Current medicinal chemistry, 2001, Vol 8, Issue 5, p509
- ISSN
0929-8673
- Publication type
Journal Article
- DOI
10.2174/0929867003373319