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- Title
Structural disorder in proteins of the rhabdoviridae replication complex.
- Authors
Leyrat, Cédric; Gérard, Francine C A; de Almeida Ribeiro, Euripedes, Jr; Ivanov, Ivan; Ruigrok, Rob W H; Jamin, Marc
- Abstract
Rhabdoviridae are single stranded negative sense RNA viruses. The viral RNA condensed by the nucleoprotein (N), the phosphoprotein (P) and the large subunit (L) of the RNA-dependent RNA polymerase are the viral components of the transcription/replication machineries. Both P and N contain intrinsically disordered regions (IDRs) that play different roles in the virus life cycle. Here, we describe the modular organization of P based on recent structural, biophysical and bioinformatics data. We show how flexible loops in N participate in the attachment of P to the N-RNA template by an induced-fit mechanism. Finally, we discuss the roles of IDRs in the mechanism of replication/transcription, and propose a new model for the interaction of the L subunit with its N-RNA template.
- Publication
Protein and peptide letters, 2010, Vol 17, Issue 8, p979
- ISSN
1875-5305
- Publication type
Journal Article
- DOI
10.2174/092986610791498939