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- Title
Annotation of non-synonymous single polymorphisms in human liver proteome by mass spectrometry.
- Authors
Chen, Ming; Yang, Bing; Ying, Wantao; He, Fuchu; Qian, Xiaohong
- Abstract
A novel strategy to annotate nsSNP-peptides in human liver proteome based on LC-ESI-MS/MS and peptide database search was proposed. Totally 115 nsSNP-peptides in human liver proteins were annotated using our method. Among them, 42 peptides were found to be amino acid mutation, 73 peptides were wild type, 5 peptides were interpreted with both mutation and wild type. The function of nsSNP-peptide was predicted using SIFT algorithm, and 2 nsSNPs were predicted to be damaged for protein function. The results here show that the strategy is very effective for annotation of nsSNP at peptide level.
- Publication
Protein and peptide letters, 2010, Vol 17, Issue 3, p277
- ISSN
1875-5305
- Publication type
Journal Article
- DOI
10.2174/092986610790780242