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- Title
Function prediction of hypothetical proteins without sequence similarity to proteins of known function.
- Authors
Kannan, S; Hauth, A M; Burger, G
- Abstract
Function prediction by sequence-similarity based methods identifies only approximately 50% of the proteins deduced from newly sequenced genomes. We have developed an approach to annotate the 'leftover proteins' i.e., those which cannot be assigned function using sequence similarity. Our method (MOPS) is pan-taxonomic, predicting fine-grained molecular function (rather than a broad functional category) with high performance. In addition, we developed a validation scheme that assesses predictions using domain-specific knowledge.
- Publication
Protein and peptide letters, 2008, Vol 15, Issue 10, p1107
- ISSN
0929-8665
- Publication type
Journal Article
- DOI
10.2174/092986608786071085