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- Title
Quasielastic light scattering study of amyloid beta-protein fibril formation.
- Authors
Lomakin, Aleksey; Teplow, David B
- Abstract
Quasielastic light scattering spectroscopy (QLS) is an optical method for the determination of diffusion coefficients of particles in solution. Here we discuss the principles of QLS and explain how the distribution of particle sizes can be reconstructed from the measured correlation function of scattered light. Non-invasive observation of the temporal evolution of particle sizes provides a powerful tool for studying protein assembly. We illustrate practical applications of QLS with examples from studies of fibril formation of the amyloid beta-protein.
- Publication
Protein and peptide letters, 2006, Vol 13, Issue 3, p247
- ISSN
0929-8665
- Publication type
Journal Article
- DOI
10.2174/092986606775338515