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- Title
Alpha-synuclein aggregation.
- Authors
Bodles, Angela M; Irvine, G Brent
- Abstract
Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.
- Publication
Protein and peptide letters, 2004, Vol 11, Issue 3, p271
- ISSN
0929-8665
- Publication type
Journal Article
- DOI
10.2174/0929866043407084