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- Title
Metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor and its pathophysiological roles.
- Authors
Higashiyama, Shigeki
- Abstract
Heparin-binding EGF-like growth factor (HB-EGF) exists as a membrane-anchored form (proHB-EGF) and as its soluble cleaved product (sHB-EGF). The conversion (ectodomain shedding) of proHB-EGF to sHB-EGF is tightly regulated by specific metalloproteinases. Ectodomain shedding plays a central role in GPCR-mediated EGFR transactivation. Antagonizing metalloproteinases can inhibit EGFR transactivation and might be of therapeutic value, for example in cardiac hypertrophy, skin remodeling and tumor growth.
- Publication
Protein and peptide letters, 2004, Vol 11, Issue 5, p443
- ISSN
0929-8665
- Publication type
Journal Article
- DOI
10.2174/0929866043406562