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- Title
Population pharmacokinetic analysis of denosumab in patients with bone metastases from solid tumours.
- Authors
Gibiansky, Leonid; Sutjandra, Liviawati; Doshi, Sameer; Zheng, Jenny; Sohn, Winnie; Peterson, Mark C; Jang, Graham R; Chow, Andrew T; Pérez-Ruixo, Juan José
- Abstract
Denosumab (XGEVA®; AMG 162) is a fully human IgG2 monoclonal antibody, which binds to the receptor activator of nuclear factor κ-B ligand (RANKL) and prevents terminal differentiation, activation and survival of osteoclasts. We aimed to characterize the population pharmacokinetics of denosumab in patients with advanced solid tumours and bone metastases.
- Publication
Clinical pharmacokinetics, 2012, Vol 51, Issue 4, p247
- ISSN
1179-1926
- Publication type
Journal Article
- DOI
10.2165/11598090-000000000-00000