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- Title
Drug-drug interaction pattern recognition.
- Authors
Duan, John Z
- Abstract
Drug-drug interaction (DDI) is an important aspect of drug development, especially for safety. When a drug is used concomitantly with other drug(s), one of the major concerns is the change of exposures, including the rate and extent of drug absorption, distribution, metabolism and elimination. To address the concerns, a common practice is to measure and report the differences between the exposure in the presence and in the absence of concomitant medication (COMED). The area under the plasma concentration versus time curve (AUC), maximum plasma concentration (C(max)) and time to reach the C(max) (t(max)) changes are usually measured in DDI studies. A usual observation is the different extents of changes among AUC, C(max) and t(max), which may raise concerns in certain therapeutic areas or some special agents. The objective of this study was to investigate the variation among changes of AUC, C(max) and t(max) in DDI studies, and its pharmacokinetic manifestation.
- Publication
Drugs in R&D, 2010, Vol 10, Issue 1, p9
- ISSN
1179-6901
- Publication type
Journal Article
- DOI
10.2165/11537440-000000000-00000