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- Title
Formulation selection and pharmacokinetic comparison of fentanyl buccal soluble film with oral transmucosal fentanyl citrate: a randomized, open-label, single-dose, crossover study.
- Authors
Vasisht, Niraj; Gever, Larry N; Tagarro, Ignacio; Finn, Andrew L
- Abstract
BioErodible MucoAdhesive (BEMA) is a new transmucosal drug delivery system designed to improve and ease the administration of drugs by this route. The first product that uses this novel delivery system contains fentanyl and is intended for the treatment of breakthrough pain in opioid-tolerant patients with cancer. The generic name is fentanyl buccal soluble film (FBSF). The objectives of this study were to compare the pharmacokinetic profile of FBSF formulations at three different pHs (pH 6, pH 7.25 and pH 8.5) and to understand the differences in the pharmacokinetics of fentanyl from FBSF compared with that of oral transmucosal fentanyl citrate (OTFC).
- Publication
Clinical drug investigation, 2009, Vol 29, Issue 10, p647
- ISSN
1173-2563
- Publication type
Journal Article
- DOI
10.2165/11315300-000000000-00000