We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Statin-associated psychiatric adverse events: a case/non-case evaluation of an Italian database of spontaneous adverse drug reaction reporting.
- Authors
Tuccori, Marco; Lapi, Francesco; Testi, Arianna; Coli, Daniela; Moretti, Ugo; Vannacci, Alfredo; Motola, Domenico; Salvo, Francesco; Rivolta, Alma Lisa; Blandizzi, Corrado; Mugelli, Alessandro; Del Tacca, Mario
- Abstract
The inhibitors of HMG-CoA reductase ('statins') are widely prescribed hypolipidaemic drugs, which have been evaluated in several clinical trials involving hundreds of thousands of patients. From a safety perspective, both clinical trials and post-marketing surveillance have demonstrated that statins are generally well tolerated, with rare serious adverse drug reactions (ADRs) that affect mainly muscle, liver and kidney. However, recent interest has been focused on a potential risk of psychiatric ADRs associated with statins, including memory loss, depression, suicidality, aggression and antisocial behaviour. Special attention is currently being paid to the potential for statin-induced sleep disorders.
- Publication
Drug safety, 2008, Vol 31, Issue 12, p1115
- ISSN
0114-5916
- Publication type
Journal Article
- DOI
10.2165/0002018-200831120-00007