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- Title
Memantine for the treatment of Alzheimer's disease: tolerability and safety data from clinical trials.
- Authors
Farlow, Martin R; Graham, Stephen M; Alva, Gustavo
- Abstract
Memantine, a moderate-affinity, uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, is the first non-cholinergic agent approved for the treatment of Alzheimer's disease (AD), and the first medication approved in the US and Europe for the treatment of moderate to severe stages of the disease. The objective of this study was to analyse safety and tolerability data from phase III memantine trials and from the open-label extensions of those trials.
- Publication
Drug safety, 2008, Vol 31, Issue 7, p577
- ISSN
0114-5916
- Publication type
Journal Article
- DOI
10.2165/00002018-200831070-00003