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- Title
Detection of spironolactone-associated hyperkalaemia following the Randomized Aldactone Evaluation Study (RALES).
- Authors
Hauben, Manfred; Reich, Lester; Gerrits, Charles M; Madigan, David
- Abstract
A population-based analysis has suggested that the publication of the RALES (Randomized Aldactone Evaluation Study) in late 1999 was associated with both the wider use of spironolactone to treat heart failure and a corresponding increase in hyperkalaemia-associated morbidity and mortality in patients also being treated with ACE inhibitors.
- Publication
Drug safety, 2007, Vol 30, Issue 12, p1143
- ISSN
0114-5916
- Publication type
Journal Article
- DOI
10.2165/00002018-200730120-00006