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- Title
Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial.
- Authors
Berthold, Heiner K; Naini, Ali; Di Mauro, Salvatore; Hallikainen, Maarit; Gylling, Helena; Krone, Wilhelm; Gouni-Berthold, Ioanna
- Abstract
HMG-CoA reductase inhibitors ('statins') have been associated with a decrease in ubidecarenone (ubiquinone) levels, a lipophilic enzyme also known as coenzyme Q10 (CoQ10), due to inhibition of mevalonate synthesis. There is speculation that a decrease in CoQ10 levels may be associated with statin-induced myopathy. The cholesterol absorption inhibitor ezetimibe increases endogenous cholesterol synthesis. The purpose of this study was to examine (i) the effects of ezetimibe and simvastatin on plasma CoQ10 levels and (ii) whether ezetimibe coadministered with simvastatin abrogates the suggested statin-induced decrease in the CoQ10 plasma levels.
- Publication
Drug safety, 2006, Vol 29, Issue 8, p703
- ISSN
0114-5916
- Publication type
Journal Article
- DOI
10.2165/00002018-200629080-00007