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- Title
Nanoemulsion loaded with lycobetaine-oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity.
- Authors
Zhao, Hui; Lu, Hua; Gong, Tao; Zhang, Zhirong
- Abstract
Intravenous injection of lycobetaine was found to show significant cytotoxic activity against (inter alia) Lewis lung carcinoma, but its therapeutic use is largely limited due to an extremely short half-life in blood. This study aimed at developing a novel lipid nanocarrier-based formulation for lycobetaine delivery. The formulation is feasible for scale-up production, exhibiting good parenteral acceptability and improved circulation characteristics.
- Publication
International journal of nanomedicine, 2013, Vol 8, p1959
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S43892