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- Title
Estimating the modulatory effects of nanoparticles on neuronal circuits using computational upscaling.
- Authors
Busse, Michael; Stevens, David; Kraegeloh, Annette; Cavelius, Christian; Vukelic, Mathias; Arzt, Eduard; Strauss, Daniel J
- Abstract
Beside the promising application potential of nanotechnologies in engineering, the use of nanomaterials in medicine is growing. New therapies employing innovative nanocarrier systems to increase specificity and efficacy of drug delivery schemes are already in clinical trials. However the influence of the nanoparticles themselves is still unknown in medical applications, especially for complex interactions in neural systems. The aim of this study was to investigate in vitro effects of coated silver nanoparticles (cAgNP) on the excitability of single neuronal cells and to integrate those findings into an in silico model to predict possible effects on neuronal circuits.
- Publication
International journal of nanomedicine, 2013, Vol 8, p3559
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S43663