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- Title
Low-weight polyethylenimine cross-linked 2-hydroxypopyl-β-cyclodextrin and folic acid as an efficient and nontoxic siRNA carrier for gene silencing and tumor inhibition by VEGF siRNA.
- Authors
Li, Jin-Ming; Wang, Yuan-Yuan; Zhang, Wei; Su, Hua; Ji, Liang-Nian; Mao, Zong-Wan
- Abstract
Targeted delivery of small interfering RNA (siRNA) has been regarded as one of the most important technologies for the development of siRNA therapeutics. However, the need for safe and efficient delivery systems is a barrier to further development of RNA interference therapeutics. In this work, a nontoxic and efficient siRNA carrier delivery system of low molecular weight polyethyleneimine (PEI-600 Da) cross-linked with 2-hydroxypopyl-β-cyclodextrin (HP-β-CD) and folic acid (FA) was synthesized for biomedical application.
- Publication
International journal of nanomedicine, 2013, Vol 8, p2101
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S42440