We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of nanoparticles binding β-amyloid peptide on nitric oxide production by cultured endothelial cells and macrophages.
- Authors
Orlando, Antonina; Re, Francesca; Sesana, Silvia; Rivolta, Ilaria; Panariti, Alice; Brambilla, Davide; Nicolas, Julien; Couvreur, Patrick; Andrieux, Karine; Masserini, Massimo; Cazzaniga, Emanuela
- Abstract
As part of a project designing nanoparticles for the treatment of Alzheimer's disease, we have synthesized and characterized a small library of nanoparticles binding with high affinity to the β-amyloid peptide and showing features of biocompatibility in vitro, which are important properties for administration in vivo. In this study, we focused on biocompatibility issues, evaluating production of nitric oxide by cultured human umbilical vein endothelial cells and macrophages, used as models of cells which would be exposed to nanoparticles after systemic administration.
- Publication
International journal of nanomedicine, 2013, Vol 8, p1335
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S40297