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- Title
Development and characterization of a new oral dapsone nanoemulsion system: permeability and in silico bioavailability studies.
- Authors
Monteiro, Lidiane M; Lione, Viviane F; do Carmo, Flavia A; do Amaral, Lilian H; da Silva, Julianna H; Nasciutti, Luiz E; Rodrigues, Carlos R; Castro, Helena C; de Sousa, Valeria P; Cabral, Lucio M
- Abstract
Dapsone is described as being active against Mycobacterium leprae, hence its role in the treatment of leprosy and related pathologies. Despite its therapeutic potential, the low solubility of dapsone in water results in low bioavailability and high microbial resistance. Nanoemulsions are pharmaceutical delivery systems derived from micellar solutions with a good capacity for improving absorption. The aim of this work was to develop and compare the permeability of a series of dapsone nanoemulsions in Caco-2 cell culture against that of effective permeability in the human body simulated using Gastroplus™ software.
- Publication
International journal of nanomedicine, 2012, Vol 7, p5175
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S36479