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- Title
In vivo tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles.
- Authors
Hsieh, Wan-Ju; Liang, Chan-Jung; Chieh, Jen-Jie; Wang, Shu-Huei; Lai, I-Rue; Chen, Jyh-Horng; Chang, Fu-Hsiung; Tseng, Wei-Kung; Yang, Shieh-Yueh; Wu, Chau-Chung; Chen, Yuh-Lien
- Abstract
Active targeting by specific antibodies combined with nanoparticles is a promising technology for cancer imaging and detection by magnetic resonance imaging (MRI). The aim of the present study is to investigate whether the systemic delivery of antivascular endothelial growth factor antibodies conjugating to the surface of functionalized supermagnetic iron oxide nanoparticles (anti-VEGF-NPs) led to target-specific accumulation in the tumor.
- Publication
International journal of nanomedicine, 2012, Vol 7, p2833
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S32154