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- Title
Amorphous silica nanoparticles aggregate human platelets: potential implications for vascular homeostasis.
- Authors
Corbalan, J Jose; Medina, Carlos; Jacoby, Adam; Malinski, Tadeusz; Radomski, Marek W
- Abstract
Amorphous silica nanoparticles (SiNP) can be used in medical technologies and other industries leading to human exposure. However, an increased number of studies indicate that this exposure may result in cardiovascular inflammation and damage. A high ratio of nitric oxide to peroxynitrite concentrations ([NO]/[ONOO(-)]) is crucial for cardiovascular homeostasis and platelet hemostasis. Therefore, we studied the influence of SiNP on the platelet [NO]/[ONOO(-)] balance and platelet aggregation.
- Publication
International journal of nanomedicine, 2012, Vol 7, p631
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S28293