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- Title
Skin regeneration with conical and hair follicle structure of deep second-degree scalding injuries via combined expression of the EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO.
- Authors
Bader, Augustinus; Ebert, Sabine; Giri, Shibashish; Kremer, Mathias; Liu, Shuhua; Nerlich, Andreas; Günter, Christina I; Smith, Dagmar U; Machens, Hans-Günther
- Abstract
Acceleration of skin regeneration is still an unsolved problem in the clinical treatment of patients suffering from deep burns and scalds. Although erythropoietin (EPO) has a protective role in a wide range of organs and cells during ischemia and after trauma, it has been recently discovered that EPO is not tissue-protective in the common β subunit receptor (βCR) knockout mouse. The protective capacity of EPO in tissue is mediated via a heteroreceptor complex comprising both the erythropoietin receptor (EPOR) and βCR. However, proof of coexpression of these heterogenic receptors in regenerating skin after burns is still lacking.
- Publication
International journal of nanomedicine, 2012, Vol 7, p1227
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S28186