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- Title
Fractionated photothermal antitumor therapy with multidye nanoparticles.
- Authors
Gutwein, Luke G; Singh, Amit K; Hahn, Megan A; Rule, Michael C; Knapik, Jacquelyn A; Moudgil, Brij M; Brown, Scott C; Grobmyer, Stephen R
- Abstract
Photothermal therapy is an emerging cancer treatment paradigm which involves highly localized heating and killing of tumor cells, due to the presence of nanomaterials that can strongly absorb near-infrared (NIR) light. In addition to having deep penetration depths in tissue, NIR light is innocuous to normal cells. Little is known currently about the fate of nanomaterials post photothermal ablation and the implications thereof. The purpose of this investigation was to define the intratumoral fate of nanoparticles (NPs) after photothermal therapy in vivo and characterize the use of novel multidye theranostic NPs (MDT-NPs) for fractionated photothermal antitumor therapy.
- Publication
International journal of nanomedicine, 2012, Vol 7, p351
- ISSN
1178-2013
- Publication type
Journal Article
- DOI
10.2147/IJN.S26468