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- Title
Targeting inflammatory kinase as an adjuvant treatment for osteosarcomas.
- Authors
Noh, Kyucheol; Kim, Kyung-Ok; Patel, Neel R; Staples, J Robert; Minematsu, Hiroshi; Nair, Kumar; Lee, Francis Young-In
- Abstract
A subset of patients with aggressive osteosarcomas responds poorly to conventional cytotoxic chemotherapy. Recent evidence from studies involving the liver, skin, stomach, and colon suggests that carcinogenesis is associated with inflammation. Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) has diverse roles in cancer and inflammation. The hypothesis of the present study is that targeted ERK1/2 inhibition will demonstrate anti-cancer effects in osteosarcoma both in vitro and in vivo.
- Publication
The Journal of bone and joint surgery. American volume, 2011, Vol 93, Issue 8, p723
- ISSN
1535-1386
- Publication type
Journal Article
- DOI
10.2106/JBJS.J.00302