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- Title
Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing.
- Authors
Cottrell, Jessica A; O'Connor, J Patrick
- Abstract
Loss of cyclooxygenase-2 activity is known to impair fracture-healing in animal models and to inhibit heterotopic ossification in humans. Cyclooxygenase-2 is the rate-limiting enzyme involved in the conversion of arachidonic acid into prostaglandins. Arachidonic acid also is a substrate for 5-lipoxygenase, which catalyzes the initial steps in leukotriene synthesis. In contrast to cyclooxygenase-2, genetic ablation of 5-lipoxygenase accelerates and enhances fracture-healing in mice. The goal of this study was to determine if systemic inhibition of 5-lipoxygenase with an orally delivered drug could accelerate fracture-healing.
- Publication
The Journal of bone and joint surgery. American volume, 2009, Vol 91, Issue 11, p2653
- ISSN
1535-1386
- Publication type
Journal Article
- DOI
10.2106/JBJS.H.01844