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- Title
Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines.
- Authors
Zwolak, Pawel; Manivel, J Carlos; Jasinski, Piotr; Kirstein, Mark N; Dudek, Arkadiusz Z; Fisher, James; Cheng, Edward Y
- Abstract
Local recurrence with subsequent osteolysis is a problem after intralesional curettage of giant cell tumor of bone, myeloma, and metastatic carcinoma. The bisphosphonate zoledronic acid (zoledronate) has been shown to reduce osteoclast activity, and its local administration is a potentially attractive therapy, especially for the osteoclast-rich giant cell tumor. The aim of this study was to analyze the elution dynamics of zoledronic acid release from acrylic bone cement and its in vitro antitumor efficacy.
- Publication
The Journal of bone and joint surgery. American volume, 2010, Vol 92, Issue 1, p162
- ISSN
1535-1386
- Publication type
Journal Article
- DOI
10.2106/JBJS.H.01679