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- Title
Intention-to-treat analysis and accounting for missing data in orthopaedic randomized clinical trials.
- Authors
Herman, Amir; Botser, Itamar Busheri; Tenenbaum, Shay; Chechick, Ahron
- Abstract
The intention-to-treat principle implies that all patients who are randomized in a clinical trial should be analyzed according to their original allocation. This means that patients crossing over to another treatment group and patients lost to follow-up should be included in the analysis as a part of their original group. This principle is important for preserving the randomization scheme, which is the basis for correct inference in any randomized trial. In this study, we examined the use of the intention-to-treat principle in recently published orthopaedic clinical trials.
- Publication
The Journal of bone and joint surgery. American volume, 2009, Vol 91, Issue 9, p2137
- ISSN
1535-1386
- Publication type
Journal Article
- DOI
10.2106/JBJS.H.01481