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- Title
Identification of progenitor cells that contribute to heterotopic skeletogenesis.
- Authors
Lounev, Vitali Y; Ramachandran, Rageshree; Wosczyna, Michael N; Yamamoto, Masakazu; Maidment, Andrew D A; Shore, Eileen M; Glaser, David L; Goldhamer, David J; Kaplan, Frederick S
- Abstract
Individuals who have fibrodysplasia ossificans progressiva develop an ectopic skeleton because of genetic dysregulation of bone morphogenetic protein (BMP) signaling in the presence of inflammatory triggers. The identity of progenitor cells that contribute to various stages of BMP-induced heterotopic ossification relevant to fibrodysplasia ossificans progressiva and related disorders is unknown. An understanding of the cellular basis of heterotopic ossification will aid in the development of targeted, cell-specific therapies for the treatment and prevention of heterotopic ossification.
- Publication
The Journal of bone and joint surgery. American volume, 2009, Vol 91, Issue 3, p652
- ISSN
1535-1386
- Publication type
Journal Article
- DOI
10.2106/JBJS.H.01177