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- Title
Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-alpha production in response to titanium particles in vitro.
- Authors
Smith, Matthew V; Lee, Michael J; Islam, Andrew S; Rohrer, Jacqueline L; Goldberg, Victor M; Beidelschies, Michelle A; Greenfield, Edward M
- Abstract
Wear debris contributes to implant loosening after total joint arthroplasty, and few advances have been made in our ability to inhibit the biological response to wear particles. Bacterial endotoxins augment the effects of wear particles in vitro and in vivo. The cytokine, tumor necrosis factor-alpha (TNF-alpha), is produced by macrophages in response to bacterial endotoxins and wear particles, and it increases osteoclast activity resulting in bone resorption and implant loosening. The phosphoinositol-3-kinase (PI3K)-Akt intracellular signal transduction pathway contributes to cytokine production in response to soluble endotoxin. We investigated the role of the PI3K-Akt pathway in the production of TNF-alpha in response to wear particles with adherent endotoxin and so-called endotoxin-free wear particles.
- Publication
The Journal of bone and joint surgery. American volume, 2007, Vol 89, Issue 5, p1019
- ISSN
0021-9355
- Publication type
Journal Article
- DOI
10.2106/JBJS.F.00615