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- Title
Stimulation of type-X collagen gene transcription by retinoids occurs in part through the BMP signaling pathway.
- Authors
Adams, Sherrill L; Pallante, Kim M; Niu, Zeling; Cohen, Arthur J; Lu, Jane; LeBoy, Phoebe S
- Abstract
Chondrocyte maturation and hypertrophy during endochondral bone formation are stimulated by both retinoids and bone morphogenetic proteins (BMPs). The type-X collagen gene, which is expressed only in hypertrophic chondrocytes, provides an excellent marker for chondrocyte maturation. We previously identified a 651-base-pair region of the type-X collagen promoter that is essential for its activation by BMP. We examined the relationship between the retinoid and BMP signaling pathways in transcriptional stimulation of the type-X collagen gene to determine whether they act independently or interact to regulate endochondral bone formation.
- Publication
The Journal of bone and joint surgery. American volume, 2003, Vol 85-A Suppl 3, p29
- ISSN
0021-9355
- Publication type
Journal Article
- DOI
10.2106/00004623-200300003-00006