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- Title
Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis.
- Authors
Childs, L M; Goater, J J; O'Keefe, R J; Schwarz, E M
- Abstract
Particle phagocytosis by macrophages induces the secretion of tumor necrosis factor-alpha, which is involved in the development of an osteolytic response. Therefore, we aimed to determine whether gene delivery of a soluble inhibitor of tumor necrosis factor-alpha (sTNFR:Fc) could prevent wear debris-induced osteolysis in a mouse model. sTNFR:Fc is a fusion protein containing the extracellular domain of the human type-I tumor necrosis factor receptor fused to the Fc region of mouse immunoglobulin. It acts by binding to tumor necrosis factor-alpha and preventing signaling through the membrane-bound tumor necrosis factor receptors.
- Publication
The Journal of bone and joint surgery. American volume, 2001, Vol 83, Issue 12, p1789
- ISSN
0021-9355
- Publication type
Journal Article
- DOI
10.2106/00004623-200112000-00004