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- Title
Dealing with innovation and uncertainty. The role of vitamin D in cancer prevention.
- Authors
Garland CF; Garland FC; Gorham ED; Lipkin M; Newmark H; Mohr SB; Holick MF
- Abstract
Vitamin D status differs by latitude and race, with residents of the northeastern United States and individuals with more skin pigmentation being at increased risk of deficiency. A PubMed database search yielded 63 observational studies of vitamin D status in relation to cancer risk, including 30 of colon, 13 of breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed the association of vitamin D receptor genotype with cancer risk.The majority of studies found a protective relationship between sufficient vitamin D status and lower risk of cancer. The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
- Publication
American Journal of Public Health, 2006, Vol 96, Issue 2, p252
- ISSN
0090-0036
- Publication type
Academic Journal
- DOI
10.2105/ajph.2004.045260