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Title

Risk Factors for Acute Kidney Injury in Patients Receiving Antibiotic Therapy; A Systematic Review and Meta -- Analysis.

Authors

Feifan LIU; Yuanmei BAI; Yan WAN; Yuhuan XIE; Peixin GUO

Abstract

[Objectives] To systematically analyze the risk factors for acute kidney injury (AKI) in patients treated with antibiotics and to conduct a meta-analysis of published clinical studies. [Methods] PubMed, Web of Science, and Embase were searched for relevant cohort and case-control studies from January 1, 2001, to October 31, 2022. Meta-analysis was performed using RevMan5. 4 and StataMP15. [Results] A total of 22 studies were included. Regarding patient factors, serum creatinine (SCr; MD -- 1.03,95% CI of -0.07 to - 0.02) was associated with increased antibiotic-associated AKI. Regarding the comorbidities and clinical factors, diabetes (OR =1.34,95% CI of 1.06 to 1.69, tumor (OR =2.07,95% CI of 1.13 to 3.79), pneumonia (OR = 1. 83,95% Of of 1.24 to 2.71), mechanical ventilation (OR = 3.44,95% CI of 1.93 to 6.12), and ICU admission (OR =2.83,95% Of of 2.13 to 3.75) increased the risk of AKI in patients receiving antibiotic therapy. Regarding drug factors, diuretics (OR = 2.76,95% CI of 2. 16 to 3. 52) increased the risk of antibiotic-associated AKI. [Conclusions] This paper may assist clinicians in predicting the risk factors for AKI in patients receiving antibiotic therapy.

Subjects

ACUTE kidney failure; DISEASE risk factors; ARTIFICIAL respiration; MEDICAL personnel; DIURETICS

Publication

Medicinal Plant, 2024, Vol 15, Issue 4, p59

ISSN

2152-3924

Publication type

Academic Journal

DOI

10.19600/j.cnki.issn2152-3924.2024.04.013

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