Title

Cytotoxicity assay of Türkiye's rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line.

Authors

Kılıç, Kubilay Doğan; Avşar, Ayşenur Kayabaş; Özkanca, Cemre; Sal, Dila Hatun; Karabey, Fatih; Yılmaz, Zeynep Simge; Uyanıkgil, Yiğit

Abstract

Aim: In this study, the cytotoxic potential of the endemic Helianthemum germanicopolitanum Bornm. plant against colon cancer is investigated. Materials and Methods: This study pioneers the investigation of medicinal applications of the H. germanicopolitanum plant, specifically targeting the HT-29 human colon cancer cell line. The phytochemical profile of the aerial parts of the plant, especially the flavonoid content, was analyzed using High Performance Liquid Chromatography (HPLC). Cytotoxic effects were then evaluated by WST-1 assays on the HT-29 cell line; this revealed time- and dose-dependent inhibition of cancer cell growth. Results: These results also highlight the need for comprehensive research into H. germanicopolitanum's unique flavonoid composition and its broader implications in cancer treatment. Conclusion: These results also highlight the need for comprehensive research into H. germaicopolitanum's unique flavonoid composition and its broader effects in cancer treatment.

Subjects

TURKEY; CISTACEAE; HIGH performance liquid chromatography; CANCER cell growth; PLANT extracts; ANTINEOPLASTIC agents; COLON cancer; CYTOTOXINS; FLAVONOIDS

Publication

Ege Journal of Medicine, 2024, Vol 63, Issue 3, p441

ISSN

1016-9113

Publication type

Academic Journal

DOI

10.19161/etd.1441204