Title

The Protective Effects of Cannabidiol on Chest Trauma-Induced Brain Injury by its Antioxidant and Anti-Inflammatory Effects.

Authors

MILLETSEVER, Adem; GULAL, Abdurrahman; ASCI, Halil

Abstract

Objective: Chest trauma-induced brain injury (CTBI) is caused by the formation of inflammatory cytokines in the lungs and blood. Cannabidiol (CBD), a non-psychoactive agent, has antioxidant, anti-inflammatory, and antiapoptotic properties. In this study, we aimed to investigate the protective effects of CBD on CTBI. Material and Method: Forty male Wistar Albino rats were divided into four groups: control, CTBI (200 g weight drop on the anterior chest wall from a height of 1 meter), CTBI+CBD (5 mg/kg, single dose intraperitoneally), and CBD. After 48 hours, rats were sacrificed under anesthesia, and brain tissues were placed in a 10% formaldehyde solution for histopathological and immunohistochemical examination. Results: In the CTBI group, hemorrhagic areas, tumor necrosis factor-alpha, caspase-3, and malondialdehyde expressions increased in histological and immunohistochemical examinations compared to the control group. CBD treatment reduced hemorrhagic areas and reversed immune expressions. Conclusion: Inflammation, apoptosis, and oxidative stress in brain tissue may develop in CTBI. These damages can be corrected with CBD treatment.

Subjects

BRAIN injuries; TUMOR necrosis factors; ANTIOXIDANTS; BLUNT trauma; ANTI-inflammatory agents; IMMUNOHISTOCHEMISTRY; LABORATORY rats; CANNABIDIOL; HISTOPATHOLOGY

Publication

Medical Journal of Suleyman Demirel University, 2024, Vol 31, Issue 4, p332

ISSN

1300-7416

Publication type

Academic Journal

DOI

10.17343/sdutfd.1514644