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- Title
A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants.
- Authors
Moya, Fernando R; Gadzinowski, Janusz; Bancalari, Eduardo; Salinas, Vicente; Kopelman, Benjamin; Bancalari, Aldo; Kornacka, Maria Katarzyna; Merritt, T Allen; Segal, Robert; Schaber, Christopher J; Tsai, Huei; Massaro, Joseph; d'Agostino, Ralph; International Surfaxin Collaborative Study Group
- Abstract
Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce the potential risks associated with the use of animal-derived products. Our objective was to compare the efficacy and safety of a novel synthetic surfactant containing a functional SP-B mimic (lucinactant; Discovery Laboratories, Doylestown, PA) with those of a non-protein-containing synthetic surfactant (colfosceril palmitate; GlaxoSmithKline, Brentford, United Kingdom) and a bovine-derived surfactant (beractant; Abbott Laboratories, Abbott Park, IL) in the prevention of neonatal respiratory distress syndrome (RDS) and RDS-related death.
- Publication
Pediatrics, 2005, Vol 115, Issue 4, p1018
- ISSN
1098-4275
- Publication type
Journal Article
- DOI
10.1542/peds.2004-2183