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- Title
Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections.
- Authors
Kimberlin, D W; Lin, C Y; Jacobs, R F; Powell, D A; Corey, L; Gruber, W C; Rathore, M; Bradley, J S; Diaz, P S; Kumar, M; Arvin, A M; Gutierrez, K; Shelton, M; Weiner, L B; Sleasman, J W; de Sierra, T M; Weller, S; Soong, S J; Kiell, J; Lakeman, F D; Whitley, R J; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group
- Abstract
The objective of this investigation was to establish the safety of high-dose (HD) acyclovir for the treatment of neonatal herpes simplex virus (HSV) disease. In addition, an estimate of therapeutic efficacy was sought, both with respect to mortality and to morbidity. Virologic efficacy of HD acyclovir was also assessed.
- Publication
Pediatrics, 2001, Vol 108, Issue 2, p230
- ISSN
1098-4275
- Publication type
Journal Article
- DOI
10.1542/peds.108.2.230