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- Title
Allergy to beta-lactam antibiotics in children.
- Authors
Ponvert, C; Le Clainche, L; de Blic, J; Le Bourgeois, M; Scheinmann, P; Paupe, J
- Abstract
Skin tests with soluble beta-lactams can be used to diagnose immediate and delayed hypersensitivity (HS) reactions to beta-lactam antibiotics. Very few studies have been performed with children with suspected beta-lactam allergy. In these studies, immediate HS to beta-lactams was diagnosed by skin tests in 4.9% to 40% of children. The diagnostic and predictive values of immediate responses in skin tests are good, because very few children with negative skin test results have positive oral challenge (OC) test results. Delayed responses in skin tests (intradermal and patch tests) have been reported in adult patients and children suffering with urticaria, angioedema, and maculopapular rashes during treatments with beta-lactam antibiotics. However, the diagnostic and predictive values of late responses are unknown. Semi-late responses in skin tests with beta-lactams have never been studied in adults or children.
- Publication
Pediatrics, 1999, Vol 104, Issue 4, pe45
- ISSN
1098-4275
- Publication type
Journal Article
- DOI
10.1542/peds.104.4.e45