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- Title
Placental leptin: an important new growth factor in intrauterine and neonatal development?
- Authors
Hassink, S G; de Lancey, E; Sheslow, D V; Smith-Kirwin, S M; O'Connor, D M; Considine, R V; Opentanova, I; Dostal, K; Spear, M L; Leef, K; Ash, M; Spitzer, A R; Funanage, V L
- Abstract
Leptin, the protein product of the ob gene, is produced by the adipocyte and seems to function as a link between adiposity, satiety, and activity. Leptin has also been found to be necessary for pubertal development, conception, and pregnancy in mice, and is increased in prepubertal children, independent of adiposity, suggesting a role in childhood growth and development. This study investigated 100 mother/newborn pairs to determine the role of leptin in neonatal development. Placental tissue was assayed for leptin mRNA to evaluate it as a source of leptin production in utero.
- Publication
Pediatrics, 1997, Vol 100, Issue 1, pE1
- ISSN
1098-4275
- Publication type
Journal Article
- DOI
10.1542/peds.100.1.e1