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Title
Assessing Genome-Wide Statistical Significance for Large p Small n Problems.
Authors
Guoqing Diao; Vidyashankar, Anand N.
Abstract
Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.