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- Title
A Novel Role of the N Terminus of Budding Yeast Histone H3 Variant Cse4 in Ubiquitin-Mediated Proteolysis.
- Authors
Wei Chun Au; Dawson, Anthony R.; Rawson, David W.; Taylor, Sara B.; Baker, Richard E.; Basrai, Munira A.
- Abstract
Regulating levels of centromeric histone H3 (CenH3) variant is crucial for genome stability. Interaction of Psh1, an E3 ligase, with the C terminus of Cse4 has been shown to contribute to its proteolysis. Here, we demonstrate a role for ubiquitination of the N terminus of Cse4 in regulating Cse4 proteolysis for faithful chromosome segregation and a role for Doa1 in ubiquitination of Cse4.
- Publication
Genetics, 2013, Vol 194, Issue 2, p513
- ISSN
0016-6731
- Publication type
Academic Journal
- DOI
10.1534/genetics.113.149898