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Title
Haploidization in Induced Saccharomyces cerevisiae by a Deficiency in Homologous Recombination.
Authors
Wei Song; Petes, Thomas D.
Abstract
Diploid Saccharomyes cerevisae strains lacking the RAD52 gene required for homologous recombination have a very high rate of chromosome loss. Two of four isolates subcultured ~20 times (~500 cell divisions) became haploid. These strains were capable of mating with wild-type haploids to produce diploid progeny capable of undergoing meiosis to produce four viable spores.