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- Title
The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to rapamycin exposure.
- Authors
Douville, Julie; David, Jocelyn; Lemieux, Karine M; Gaudreau, Luc; Ramotar, Dindial
- Abstract
We show that mutants lacking either the phosphatase activator Rrd1 or the phosphatase Pph3 are resistant to rapamycin and that double mutants exhibit a synergistic response. This phenotype could be related to an inability of the mutants to degrade RNA polymerase II, leading to transcription of critical genes that sustain growth.
- Publication
Genetics, 2006, Vol 172, Issue 2, p1369
- ISSN
0016-6731
- Publication type
Journal Article
- DOI
10.1534/genetics.105.046110