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- Title
Pilot trial of memantine in the treatment of posttraumatic stress disorder.
- Authors
Battista, Matthew A; Hierholzer, Robert; Khouzam, Hani Raoul; Barlow, Alycia; O'Toole, Siobhan
- Abstract
This multiple case series was initially designed as a prospective, open-label, 12-week trial investigation evaluating memantine (Namenda) for the treatment of psychiatric and cognitive symptoms associated with PTSD. In a selected, small sample of individuals (n = 4) with combat PTSD, treatment with memantine produced consistent improvement on a delayed recall measure of memory, variable reduction of depressive symptoms, and variable reduction in hyperarousal symptoms. These data suggest potential positive treatment outcomes, both cognitively and psychiatrically, and provide rationale for future double-blind, placebo-controlled studies of memantine in PTSD.
- Publication
Psychiatry, 2007, Vol 70, Issue 2, p167
- ISSN
0033-2747
- Publication type
Journal Article
- DOI
10.1521/psyc.2007.70.2.167